Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The Big Tech backlash will spread to technology industry employees in 2018, as many question whether the work they do really is saving the world.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
The largest flawless vivid blue diamond in the world is to go on sale today at Christie's auction house.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Everyone on Wall Street, Main Street and Washington keeps forgetting the fundamentals of market cycles. Please remember: Investors Business Daily's Bill O'Neill, author of 'How to Make Money in Stocks, ' says market cycles average 3.75 years up, nine months down.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
For the students interested in comparing school options around the world, US News released the fourth edition of its annual Best Global Universities rankings.
Trends and targets in antiviral phototherapy
In addition to a large, educated workforce to choose from, companies are also attracted to Arizona’s pro-business regulatory climate, which ranks No. 13 in the Mercatus Center’s Freedom in the 50 States. The study cites Arizona’s right-to-work law, liability laws and eminent domain reform.
The Baltic Dry index, a measure of the trade in bulk commodities, has been touching historic lows. China, which in 2014 overtook the US as the biggest trading nation, this month reported double-digit falls in both exports and imports in January. In Brazil, which is experiencing its worst recession in more than a century, imports from China have collapsed.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
But at the end of a madcap Golden Globes (Ms. Fey toasted it as 'the beautiful mess we hoped it would be'), the major honors soberly ended up with the favorites. David O. Russell's con-artist caper 'American Hustle' led with three awards, including best film comedy. And despite missing out in the other six categories it was nominated in, the unflinching historical drama '12 Years a Slave' concluded the night as best film drama.
Novel biosensing methodologies for ultrasensitive detection of viruses
The Thomson Reuters Top 100 global innovators program identifies innovators annually through an in-depth analysis based on a series of patent-related metrics that analyze what it means to be truly innovative.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
在本届戛纳电影节上，女性电影制作人以及相关女性话题曾广受关注成为宣传主题。28年来，戛纳首次以女导演拍摄的电影拉开序幕，伊莎贝拉?罗西里尼(Isabella Rossellini)成为“一种关注”单元评审团主席，莎尔玛?海雅克(Salma Hayek)主持讨论会高调探讨女性角色在电影中的意义。可以讨论的话题有许多，但是真的有何改变吗？数字似乎更能说明问题，主竞赛单元的19部入围作品仅有2部来自女性导演。而后发生的“高跟鞋门”，更有.....面对外界对于影展涉嫌性别歧视的负面消息，艺术总监蒂埃里?弗雷莫(Thierry Frémaux)一点儿反应都没。他只是说，戛纳电影节的举办有着及其不公平的高标准，参展影片不能申请其他诸如威尼斯或柏林电影节。这难道是建议人们去“攻击奥斯卡”？
ACE2 as a potential therapeutic target for pandemic COVID-19
"Twenty Two" featuring the tales of 22 comfort women became the first Chinese documentary to surpass 100 million yuan at the box office.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
“Airbnb is here to stay,” Mr. Gottsegen said. “Instead of fighting it, we should wrap our arms around it and make it better.”
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
According to China's business magazine New Fortune's 2018 Chinese wealthy list, the top 10 tycoons' total wealth reached 1.72 trillion yuan, accounting for 18% of the combined wealth of the list's total 500, and the top 10's personal wealth has surpassed 100 billion yuan for the first time.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
This ranking measures the quality and breadth of the schools’ postgraduate programmes. It is based on their performance in the four main rankings published by the FT each year: MBA, Executive MBA, Masters in Management and Executive Education. Only schools that take part in all four rankings are eligible for a full score.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
If all this comes to pass, Huberty estimates that Apple's addressable smartphone market in China, which had dwindled to 10%, could triple to nearly 30%.
Latest ECB projections predict the eurozone, which has struggled to grow as strongly as the US or UK, will grow 1.7 per cent in 2016 after hitting 1.5 per cent growth this year as QE bolsters the economy.
Influenza neuraminidase: A druggable target for natural products
Chinese imports fell 18.8 per cent in October from the same month a year earlier, a slight improvement from the 20.4 per cent year-on-year fall in September. Sharply lower prices of oil and other commodities also helped scythe the bill.
1. Battle of the Sexes
The work suits Carlson who has been into singing and musical theater her whole life.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
But the economic base for these capabilities is steadily declining.
The role of biosensors in the detection of emerging infectious diseases
It grows naturally into the mold's shape.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
企业也在其他方面受益。英国国家电网公司的业务分析经理克雷格?罗拉森(Craig Rollason)表示，他通过指导一位Teach Firste人提高了自己的指导技巧。
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
“…started swearing during the interview.”
The Cems masters in management, the international programme provided through a network of 30 business schools, is ninth, down five places from 2015, when it was last ranked.
2. “闪光的密切：纳撒尼尔·多斯基与杰罗姆·希勒的电影”(Luminous Intimacy: The Cinema of Nathaniel Dorsky and Jerome Hiler)。赞美纽约电影节，感谢纽约电影节，举办了这样一次令人赞叹的双人回顾影展。
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The singer/songwriter Dua Lipa has been steadily releasing a string of singles since 2015, beginning with the flirty "Be the One" and finally hitting the jackpot with "Hotter Than Hell" – both collected here on her debut album.
Season\'s greetings and sincere wishes for a bright and happy New Year!
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
In 2011 the owner of the tomb was identified as Liu Fei (169BC-127BC) the first king of Jiangdu an autonomous kingdom within the Han Dynasty according to China News.
Making Airbnb go away might not be so easy. A recent Quinnipiac poll found that 56 percent of the responders thought New Yorkers should be allowed to rent rooms out to strangers. “We don’t want to turn into hotels, but at the same time people want to rent out their apartments sometimes,” said Paul R. Gottsegen, the president of Halstead Management Company, which manages 250 residential properties in the city.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
How could we not include the ancient Chinese theory of interior aesthetics? Where your desk is situated is the most important aspect to freeing the energy in your space. Place your desk so that you face the door— the ultimate power position. Avoid placing your desk against a wall with your back facing the door, as it will interfere with the balance of your chi.
However, its alumni are the most mobile internationally, with 85 per cent of the class of 2014 having worked abroad.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
7. Kristen Stewart
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Bella is the youngest model on the list, having just turned 21 last month.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
As early as 2008, wearable technology—which can range in anything from measuring your heart rate to curating music based on your mood—has been touted as the next big moment in consumer electronics.
Recognize me?: image via blog.discoverymagazine.com
德系三巨头：由于奔驰的几款低价产品不可避免地会损害它“要么最好，要么什么都不是”(the best or nothing)的商誉，该公司也开始陷入低迷。而即将推出的新7系轿车则会进一步巩固宝马在美国富人圈中的地位。另外，起价30,795美元的奥迪A3，很可能会使奥迪的销量较2014年增长15%，新款Q7也将进一步提高奥迪的利润。
特里萨?梅(Theresa May)依然面临着党内阻力。自由民主党(Liberal Democrats)的智者兼领导人文斯?凯布尔(Vince Cable)依然认为脱欧可能不会真的发生。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
It was there in Rossella Jardini’s Moschino, from the bows and bouffants of spring-summer 2009 to the Mary Quant-inspired spring 2013 collection.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The report also shows that despite the rising pension insurance balance since 2012, the payable number of months fell to 17.7 months last year from 19.7 months in 2012.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
These rankings use a different methodology from the overall ranking based on academic research performance in each specific subject.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Economic forecasters are counting on 2014 to be a breakout year. But whether the economy finally moves past its sluggish growth will rest on several forces playing out differently than they have since the recovery began. Some of the key questions:
Asli Erdogan, a novelist of the “dark, pessimistic,” is struggling to process her own grim experience: months in prison.
We will continue to pursue a proactive fiscal policy and a prudent monetary policy.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
The big question is what oil prices will do in 2015. Oil prices are unsustainably low right now – many high-cost oil producers and oil-producing regions are currently operating in the red. That may work in the short-term, but over the medium and long-term, companies will be forced out of the market, precipitating a price rise. The big question is when they will rise, and by how much.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
3.Oh, yeah. That makes sense. – Because option B involves admitting that I am clueless。
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
If successful, Hurun estimates that Mr Wang’s net worth could soar past $50bn, making him one of the world’s 10 richest men.
After months have passed without a culprit in her daughter's murder case, Mildred Hayesmakes a bold move, painting three signs leading into her town with a controversial message directed at William Willoughby, the town's revered chief of police. When his second-in-command Officer Dixon, an immature mother's boy with a penchant for violence, gets involved, the battle between Mildred and Ebbing's law enforcement is only exacerbated.
The expansion would be considered impressive in most markets, but it represents an ongoing slowdown for China, the world's second-largest film territory and a continual source of growth for Hollywood for the better part of a decade.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
“It comes down to answering these questions: how do you continue to iterate the platform, how do you continue to augment the team, and how do you build a tapestry of alliances with partners that will accelerate your growth?” Case said.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Google's brand is now worth more than 109 billion U.S. dollars, around 2 billion dollars more than Apple, making it the most lucrative in the world.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The new numbers, reported by a tracking initiative called the Global Carbon Project and published in the journal Nature Geoscience, came on the eve of a United Nations summit meeting meant to harness fresh political ambition in tackling climate change. Scientists said the figures showed that vastly greater efforts would be needed to get long-term global warming within tolerable limits.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
While British schools moved up two places on average, French schools, the largest group from any one country, fell one place on average. EMLyon Business School dropped outside the MBA ranking and lost 15 places overall, while Edhec Business School failed to make it into the Executive MBA ranking and lost eight places overall as a result.
Businesswomen are booming in Asia: The whole region makes a strong showing, from China and Singapore to New Zealand and Thailand. Entrepreneurship is on the rise: see Zhang Xin (No. 50) , Sun Yafang (No. 77) and Solina Chau (No. 80). And Asian region women are showing their political might, from newcomer Park Geun-hye, the South Korean president (No. 11) and Burmese dissident and parliamentarian Aung San Suu Kyi (No. 29) to Australian PM Julia Gillard (No. 28) and Thai Prime Minister Yingluck Shinawatra (No. 31).
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Britain saw a 66 percent increase in its foreign-born population between 2004 and 2014. Voters who chose “leave” in the recent referendum overwhelmingly cited immigration as their main concern.
The unemployment rate has plunged over the past three years to 5.8% from 8.6%, but almost nobody, including the Federal Reserve, thinks the labor market is really that healthy.
A facile assay for rapid detection of COVID-19 antibodies
"I want to tell you what happened I opened the envelope and it said Emma Stone, La La Land and that is why I took such a long look at Faye and at you. I wasn't trying to be funny. This is Moonlight for best picture," Beatty told the shocked crowd as he explained the blunder.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
3. Your boss received your résumé from a contact of a contact。
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
十年前，斯蒂尔作为一名成功的投资顾问在世界电信展（ITU World）上发言。世界电信展是联合国主导的一项活动，重点是科技在政府中的应用。同一周，加州经历了史上第一次州长罢免选举。斯蒂尔不敢相信，在如此重要的选举中，会出现这种不合时宜的平台故障（三年前才刚刚发生了臭名昭著的佛罗里达州总统选举罢免），所以她决定凭一己之力来解决这个问题。到目前为止，共有169个国家使用了Everyone Counts的电子投票平台，包括波斯尼亚黑塞哥利亚和奥斯卡奖评审委员会。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
7、Bad body language habits
Anti-HIV drug repurposing against SARS-CoV-2
Consumer prices continued to rebound from an August dip, accelerating 0.2 percentage points to 2.1 per cent year on year, bang-on analysts’ median forecast.
Do not forget why you're attending these conferences, who you're doing this for -- we are your own children. You are deciding what kind of world we will grow up in. Parents should be able to comfort their children by saying "everyting's going to be alright" , "we're doing the best we can" and "it's not the end of the world". 不要忘记你们为何而来到这里开会，你们为谁做事情？我们是你们的下一代，你们正在决定我们将要在一个什么样的环境中成长，父母需要能够宽慰孩子们，告诉他们“一切都没问题，那不是世界末日，我们正在尽其所能的改变”。
Length-scale dependence of protein hydration-shell density
UK schools account for more than a third of all graduates from the top 50 pre-experience programmes and not only attracted nearly half of all female students but also almost half of all international students. Indeed, 94 per cent of students enrolled in a UK MiF pre-experience programme in 2014 were from overseas. About 85 per cent of these students were from outside the European Economic Area, including 55 per cent of the overall number from mainland China.
But I don't think you can say that to us anymore. Are we even on your list of priorities? My father always says "You are what you do, not what you say." 但我不能再相信这样的话了，孩子们还是你们的优选名单吗？我爸爸总是说：“听其言，观其行，是认识一个人最好的方法”。
Be passionate about learning.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
By the end of 2015, Shanghai's population of migrant residents had decreased to 9.8 million, comprising 40.6 percent of the city's roughly 24 million permanent residents, according to statistics released by the Shanghai Municipal Statistics Bureau on Monday.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
About this collection
We took further steps to implement the Internet Plus action plan and the national big data strategy.
We learned that nothing brings people together like the sun hiding behind the moon.